Nanoparticle uptake in worms


This image shows a 3D rendering of the tiny roundworm Caenorhabditis elegans, which was exposed to cobalt nanoparticles in soil and then fixed in a quartz capillary. C. elegans is a model organism for exposure experiments because it has a short lifecycle and, being transparent, allows high-resolution imaging of its internal organs. The two distinct objects visible in the centre of the image are embryos in the uterus of a preserved adult hermaphrodite C. elegans, behind which abundant cobalt nanoparticles (green dots) can be seen in the creature’s intestine.

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The image was created at the ESRF’s nano-imaging beamline ID16A using phase contrast absorption X-ray nanotomography with a beam size of 20 x 37 nm, while the presence of cobalt was confirmed using X-ray fluorescence tomography. The study was carried out by users from the Norwegian University of Life Sciences (CERAD) and the University of Antwerp. 



Combined nano-CT and nano-XRF imaging of cobalt nanoparticles in Caenorhabiditis elegans,, S. Cagno, D.A. Brede, G. Nuyts, F. Vanmeert, A. Pacureanu, R. Tucoulou, P. Cloetens, G. Falkenberg, K. Janssens, B. Salbu, and O.C. Lind, Anal. Chem. (2017); doi: 10.1021/acs.analchem.7b02554.


Cobalt nanoparticle uptake by C. Elegans

Top image: Image credit: S. Cagno, Norwegian University of Life Sciences.