logo_pathogen.gif
Structural and Molecular Biology
of
Host-Pathogen Interactions

5-6-7 February, 2008
Venue: ESRF Auditorium

TUESDAY
February 5th, 2008
11:00-12:00 Registration
12:00-13:30 Lunch at the ESRF restaurant

Session 1
BACTERIAL ADHESION
Chair: Andrea Dessen
13:30-13:40 Introduction by Sine Larsen, ESRF, Director of Research
13:40-14:20 The chaperone-usher pathway of pilus biogenesis: structural basis of the assembly process of host recognition Gabriel Waksman
ISMB London, UK
14:20-14:45 Atomic resolution basis for host cell recognition by apicomplexan parasites and pathogenic bacteria Stephen Matthews
Imperial College London, UK
14:45-15:10 Function and Assembly of Type IV secretion systems Eric Cascales
IBSM, Marseille, France
15:10-15:30 Coffee break

Chair: Laurent Terradot
15:30-16:10 Assembly of the Yersinia Ysc Injectisome Guy Cornelis
University of Basel, Basel, Switzerland
16:10-16:35 Regulation of type III secretion needle formation in Pseudomonas aeruginosa Andrea Dessen
IBS, Grenoble, France
16:35-17:00 Instabilities and irregularities promote virulence in Group A Streptococcus M1 protein Partho Gosh
University of California, San Diego, USA
17:00-17:20 Coffee break

Session 2
VIRUS AND HOST CELL FACTORS
Chair: Winfried Weissenhorn
17:20-18:00 HIV assembly in monocytic cells Mark Marsh
MRC Cell Biology Unit, London, UK
18:00-18:25 Assembly of ESCRT machinery on membranes and disassembly by
Vps4 AAA-ATPase		 Olga Perisic
MRC Laboratory for Molecular Biology, Cambridge, UK
18:25-18:30 Concluding remarks
18:30- 19:30 POSTER SESSION & Aperitif
19:45 Bus departure from the ESRF to the restaurant
20:00 Workshop dinner at the Restaurant Novotel
22:00 Bus departure from the restaurant to the ESRF Guesthouse
WEDNESDAY
February 6th, 2008
09:00-12:00 ESRF Users' Meeting Plenary Session
12:00-13:30 Lunch at the ESRF restaurant
13:30-15:00 MX Parallel Session

Session 2bis
VIRUS AND HOST CELL FACTORS
Chair: Dominique Housset
15:20-16:00 Ligand Recognition and Plasticity in HIV Envelope Glycoprotein gp120 Wayne Hendrickson
Columbia University, New York, USA
16:00-16:25 Structural insights into the function of the PB2 subunit of influenza virus polymerase Stephen Cusack
EMBL, Grenoble, France
16:25-16:55 Coffee break

Chair: Daniel Panne
16:55-17:20 Structural Analysis of Virus-Receptor Interactions Thilo Stehle
Universität Tübingen, Tübingen, Germany
17:20-17:45 Structural Enigmas Concerning Transcription and Replication of Rabies Virus Robert Ruigrok
UJF-EMBL-CNRS, Grenoble, France
17:45-18:25 Plenary 6 Dave Stuart
MRC Structural Biology, Oxford, UK
18:25-18:30 Concluding remarks
18:30- 19:50 POSTER SESSION & Aperitif
20:00-22:30 Users' Meeting Dinner
(Transport will be organized at 22:30 from the ESRF to downtown Grenoble)
THURSDAY
February7th, 2008

Session 3
IMMUNE RESPONSE
Chair: Gérard Arlaud
09:00-09:45 The central steps of the Complement System Piet Gros
Bijvoet Center of Biomolecular Research, Utrecht, The Netherlands
09:45-10:10 TRIM21: A novel mammalian IgG-receptor that mediates autoimmune disease Leo James
MRC Laboratory of Molecular Biology, Cambridge, UK
10:10-10:35 The Structural Basis of T-Cell Receptor Recognition Craig Clements
Monash University, Clayton, Australia
10:35-10:50 Coffee break

Chair: Stephen Cusack
10:50-11:35 Mutliple roles of Peptidoglycan Recognition proteins in Drosophila Bruno Lemaitre
Global Health Institute, Lausanne, Switzerland
11:35-12:00 An atomic model of INF-b enhanceosome structure Daniel Panne
EMBL, Grenoble, France
12:00-12:40 Plenary 4 John Skehel
MRC National Institute for Medical Research, London, UK
12:40-12:45 Concluding remarks Stephen Cusack
EMBL, Grenoble, France