All SOS requests (either starting from liquid or grids) should be associated with the SOSquestions document for technical feasibility evaluation. The document should be sent by email to cryo-em@esrf.fr

Sample Quality required:

  • Size-exclusion purified protein or protein complexes
  • Stability characterization including DLS, SEC-MALLS, etc
  • Freeze-thaw SEC profiles

Computing infrastructure required in host lab:

  • Access to cryoEM image processing software
  • Access to GPU/CPU clusters
  • Preferably proven cases of determining cryoEM structures