Programme
Wednesday 21 March
13.00 – 14.00 Registration in the ESRF entrance hall
Session 1: Structural Biology with Impact in Biomedical Applications
ESRF auditorium
14.00 – 14.15 Welcome
14.15 – 15.00 Chris Tate (MRC LMB)
"G protein-coupled receptors: from crystals to the clinic"
15.00 – 15.45 Herbert Nar (Boehringer Ingelheim)
"Exploiting allosteric inhibition of GTP Cyclohydrolase I for treating pain disorders"
15.45 – 16.00 Monika Oberer (University of Graz)
"The crystal structure of monoacylglycerol lipase form M. tubercolosis
reveals the basis for specific inhibition"
16.00 – 16.15 Gérard Bricogne (Global Phasing Ltd)
"Achieving higher performance in high-throughput compound and
fragment screening campaigns by the use of "Club Class" data
collection with Pipedream and CRIMS"
16.15 – 16.45 Tea/coffee break
16.45 – 17.15 Magali Mathieu (Sanofi)
"19F-NMR Fragment Screening at Sanofi"
17.15 – 17.30 María José Sánchez-Barrena (Spanish National Research Council)
"An aminophenothiazine inhibitor of the NCS-1/Ric8a complex
regulates synaptic function in fragile X syndrome"
17.30 – 17.45 Maayan Gal (Migal - Galilee research center)
"Discovery and development of small-molecule PPIs inhibitor by
computational and biophysical tools"
17.45 – 18.00 Robbie P. Joosten (Netherlands Cancer Institute)
"PDB-REDO: high throughput crystallographic model optimisation"
18.00 – 18.30 Poster Clips
18.30 – 20.30 Wine and cheese buffet, Poster Session in the EMBL-ILL Hallway
Thursday 22 March
Session 2: Infrastructures for Translational Research
ESRF auditorium
09.00 – 09.10 Anastassis Perrakis (Netherlands Cancer Institute)
"Introduction to iNEXT"
09.10 – 09.30 Irina Cornaciu (EMBL Grenoble)
"High-throughput, automated crystallography pipelines for drug discovery"
09.30 – 09.50 Sridhar Sreeramulu (Goethe University)
"NMR quality control and screening capabilities for fragments and beyond"
09.50 – 10.10 Alice Douangamath (Diamond Light Source)
"Fragment screening at Diamond's XChem facility"
10.10 – 10.30 Alexander Fish (NKI)
"Biophysical methods for checking protein-ligand interactions"
10.30 – 11.00 Tea/coffee break
11.00 – 11.30 Lucia Banci (University of Florence)
"Why Instruct is strategic for industry?"
11.30 – 12.15 Matthias Frech (Merck-Serono)
"Drug design in the wider context"
12.15 – 12.30 Organisation of Working Groups - Anastassis Perrakis
12.30 – 14.00 Lunch break (EPN Campus restaurant)
Session 3: Academia - Industry: Fostering Interactions
ESRF auditorium
14.00 – 14.45 Sandra W. Cowan-Jacob (Novartis Institutes for Biomedical Research)
"Using structural biology to find new approaches to treat Chronic
Myelogenous Leukemia"
14.45 – 15.30 Puja Pathuri (Astex Pharmaceuticals)
"Fragment based drug discovery at Astex"
15.30 – 16.00 Harmut Oschkinat (Leibniz-Institut für Molekulare Pharmakologie)
"Insight into small molecule binding to the neonatal Fc teceptor
by X-ray crystallography and 100 kHz magic-angle-spinning NMR"
16.00 – 16.30 Tea/coffee break
16.30 – 18.30 Working Groups Discussions
19.30 – 22.00 Workshop dinner (restaurant Fantin Latour in Grenoble)
Friday 23 March
Session 4: Emerging Methods - Complementary Approaches
ESRF auditorium
09.00 – 09.40 Roger Williams (MRC LMB)
"Using HDX-MS, X-ray crystallography and cryo-EM to understand inhibition, activation and dynamics of the PI 3-kinase superfamily"
09.40 – 10.20 Ilaria Ferlenghi (GSK Vaccines)
"Structural vaccinology: a three-dimensional view of vaccine
development"
10.20 – 10.35 Pavel Macek (NMR)
"NMR reveals changes of Hsp90 dynamics upon ligand binding"
10.35 – 11.00 Tea/coffee break
11.00 – 12.00 Working Groups Wrap-Up
12.00 – 12.45 Stephen Cusack (EMBL Grenoble)
"The mechanism of transcription by influenza polymerase and how to
inhibit it"
12.45 – 13.00 Closing Remarks
13.00 End of Meeting