EMBO Practical Course: Exploiting Anomalous Scattering in Macromolecular Structure Determination

   6 - 10 June 2011

ESRF, Grenoble & EMBL Grenoble Outstation - France

Venue: ILL Chadwick Amphitheatre

 Organising Committee
ESRF Grenoble Daniele de Sanctis, Christoph Müller-Dieckmann, Gordon Leonard, Matthew Bowler, Didier Nurizzo, Claudine Roméro
EMBL Grenoble Outstation Hassan Belrhali, Andrew McCarthy
EMBO Lynne Turnbull

 Scope of the course

This practical course addresses young scientists who intend to apply single and multiple wavelength anomalous scattering (SAD & MAD) methods in macromolecular structure determination.

The course aims to impart the theoretical and practical basis for the 3-dimensional structure determination of bio-macromolecules using Anomalous Dispersion techniques.

Through a series of lectures, software demonstrations, practicals on the ESRF beamlines and tutorials, participants will get insights into all aspects of the structure determination process, including:

• beamline instrumentation
• good data collection practice and processing
• heavy atom substructure determination
• phasing

There will also be sessions focusing on automated structure solution procedures and newer methods which exploit small anomalous scattering signals from crystals of native macromolecules. 

A session will be dedicated to highlight structures that have been solved recently using anomalous dispersive techniques on the ESRF beamlines.

We look forward to welcoming you in Grenoble!

The Organisers

Co-sponsors: